The meaning of SYSTEMIC is of, relating to, or common to a system. How to use systemic in a sentence. Systematic and Systemic: Usage Guide Systemic effect, an adverse effect of an exposure that affects the body as a whole, rather than one part Systemic inflammatory response syndrome, an inflammatory state affecting the whole body, frequently in response to infection Systemic lupus erythematosus, a chronic autoimmune connective tissue disease that can affect any part of the body SYSTEMIC definition: of or relating to a system, especially when affecting the entirety of a thing. See examples of systemic used in a sentence. Systematic approach or systemic approach? Learn how to use systematic and systemic with definitions and example sentences. Systemically vs. systematically. Systemic sclerosis (scleroderma) causes widespread skin thickening and can involve the lungs, kidneys, and esophagus. Infections can also be systemic. A urinary tract infection is localized. But when bacteria from that infection enter the bloodstream and trigger a body-wide response, the problem becomes systemic. This is what happens in sepsis. 4 meanings: 1. → another word for systematic (sense 1), systematic (sense 2) 2. physiology (of a poison, disease, etc). Click for more definitions. The simple definition of SYSTEMIC is of or relating to an entire system. Systemic – born out of a deep desire to bring our vision to life, to create something authentic and to craft pieces that embody timelessness and individuality. A systemic disease is one that affects a number of organs and tissues, or affects the body as a whole. [1] It differs from a localized disease, which is a disease affecting only part of the body (e.g., a mouth ulcer). SYSTEMIC definition: 1. A systemic drug, disease, or poison reaches and has an effect on the whole of a body or a plant…. Learn more.